مقالات

The mechanisms of action of vacuum‎ assisted closure: More to learn

Abstract

THERE  HAS  BEEN  RAPID  ADOPTION  OF  VACUUM-ASSISTED

CLOSURE (VAC) TECHNOLOGY to treat many acute and chronic wounds despite a rudimentary under-standing of the biologic mechanisms of action and few well-controlled, prospective, randomized clini-cal trials of its use.

An expert panel carried out a selected review of published literature regarding the mechanisms of action of the VAC device in the context of published clinical studies.

The current literature suggests primary mecha-nisms of action of the VAC device may include the following: (1) drawing the wound edges together;

(۲)  stabilization  of  the  wound  environment;

(۳) decrease in wound edema and removal of wound exudate; and (4) microdeformations of the wound surface. Secondary effects include increased angiogenesis, granulation tissue formation, and, in some cases, a decrease in bacterial bioburden.

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