Received: 9 April 2010 / Published online: 23 December 2010 Springer-Verlag 2010
Introduction Vacuum-assisted closure (VAC) therapy is a sophisticated development of a standard surgical procedure. The purpose of this study is to evaluate the clinical efficacy of managing adult osteomyelitis with VAC therapy.
Materials and methods We included a total of 68 patients that developed osteomyelitis with Cierny–Mader types 2, 3 and 4, and required open wound management between March 2005 and February 2009. In this study, 35 of these patients were treated by VAC therapy and the other 33 by conventional wound management. The patients were well compared with type, debridement times, wounds coverage, bacteriology and recurrence.
Results Of the study, the patients treated by VAC therapy had a significantly reduced recurrence (1 vs. 7 wounds, P \ 0.05), decreased rate of further autodermoplasty or flap surgery (17 vs. 26 wounds, P \ 0.05), and increased cases of bacterial species cultures to negative (29 vs. 15 wounds, P \ 0.05), debridement times and type were similar between the two groups.
Conclusion VAC therapy represents a good clinical effi-cacy in treating osteomyelitis; it can promote the granu-lation tissue formation, bacterial clearance, and reduce the needs for tissue transfer and muscle flaps in patients. In addition, it could be used as an adjuvant for the eradication of osteomyelitis and improving soft-tissue management, it may be more suitable for treating osteomyelitis with soft-tissue problems.